The aim of our team is to understand how nuclear architecture can be used to encode regulatory information. Using a combination of cell biology, biochemistry and genetic approaches, we are identifying structural players which contribute to this spatial positioning. Focusing on ribosome biogenesis, we are studying how specific intranuclear position affects transcriptional co-regulation with ribosomal regulon, and the function of newly discovered intranuclear rRNA surveillance machinery. From the identification of molecular components, we are trying to characterize this new regulatory principle: the spatial regulation. Building on finding in yeast, we are developing hetero-specific complementation approaches to extend our knowledge to others eukaryots.
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Main collaborations :
Herbert Tschochner, Universität Regensburg (Allemagne)
Pierre Thuriaux, CEA saclay, France
Dr Joost Zomerdijk, College of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee, UK
Alain Jacquier, Micheline Fromont-Racine, Cosmin Saveanu, Unité des interactions macromoléculaires, Institut Pasteur, Paris, France
Christophe Zimmer, Imagerie et modélisation, Institut Pasteur, Paris
Joachim Griesenbeck, Institute for Biochemistry, Genetics and Microbiology, 93040 Regensburg, Germany
Laurent héliot, IRI, 1, rue du Pr. Calmette BP 447 - 59021, LILLE Cedex, France
Patrick Schultz, Institute of Genetics and
Molecular and Cellular Biology
Christophe Carles, Directeur de Recherche CEA, Institut de biologie et de technologies de Saclay |
