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Dynamique et Dysfonctionnements de la Synthèse des Ribosomes



Publications de l'équipe


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Bailly A, Perrin A, Bou Malhab LJ, Pion E, Larance M, Nagala M, Smith P, O'Donohue MF, Gleizes PE, Zomerdijk J, Lamond AI, Xirodimas DP. (2015) The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway. Oncogene. 2015 Apr 13. doi: 10.1038/onc.2015.104. [Epub ahead of print]
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Henras A, O’Donohue MF, Plisson-Chastang C, Chakraborty A, Gleizes PE (2015) An overview of pre-rRNA processing in eukaryotes. WIREs RNA, 6: 225-42. doi: 10.1002/wrna.1269
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Nieminen TT, O'Donohue MF, Wu Y, Lohi H, Scherer SW, Paterson AD, Ellonen P, Abdel-Rahman WM, Valo S, Mecklin JP, Järvinen HJ, Gleizes PE, Peltomäki P (2014) Germline mutation of RPS20, a ribosomal protein gene, predisposes to hereditary nonpolyposis colorectal carcinoma without DNA mismatch repair deficiency. Gastroenterology 147, 595-598

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Ohmayer U, Gamalinda M, Sauert M, Ossowski J, Poll G, Linnemann J, Hierlmeier T, Perez-Fernandez J, Kumcuoglu B, Leger-Silvestre I, Faubladier M, Griesenbeck J, Woolford J, Tschochner H, Milkereit P (2013) Studies on the assembly characteristics of large subunit ribosomal proteins in S. cerevisae. PLoS ONE. 8, e68412.
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Landowski M, O’Donohue MF, Buros C, Ghazvinian R, Montel-Lehry N, Vlachos A, Sieff CA, Newburger PE, Niewiadomska E, Matysiak M, Glader B, Atsidaftos E, Lipton JM, Beggs AH, Gleizes PE, Gazda HT (2013) Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia. Hum Genet. 132, 1265-1274.

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Preti M, O'Donohue MF, Montel-Lehry N, Bortolin-Cavaille ML, Choesmel V, Gleizes PE (2013) Gradual processing of the ITS1 from the nucleolus to the cytoplasm during synthesis of the human 18S rRNA. Nucleic Acids Res. 41: 4709-4723.
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Carron C, Balor S, Delavoie F, Plisson-Chastang C, Faubladier M, Gleizes PE, O'Donohue MF (2012) Post-mitotic dynamics of pre-nucleolar bodies is driven by pre-rRNA processing. J Cell Sci. 125: 4532-4542.
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Gazda HT, Preti M, Sheen MR, O'Donohue MF, Vlachos A, Davies SM, Kattamis A, Doherty L, Landowski M, Buros C, Ghazvinian R, Sieff CA, Newburger PE, Niewiadomska E, Matysiak M, Glader B, Atsidaftos E, Lipton JM, Gleizes PE, Beggs AH (2012) Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia. Hum Mutat. 33: 1037-1044.
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Ellis SR, Gleizes PE (2011) Diamond Blackfan anemia: ribosomal proteins going rogue. Semin. Hematol. 48: 89-96.
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Carron C, O'Donohue MF, Choesmel V, Faubladier M, Gleizes PE. (2011) Analysis of two human pre-ribosomal factors, bystin and hTsr1, highlights differences in evolution of ribosome biogenesis between yeast and mammals. Nucleic Acids Res. 39: 280-291.
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O'Donohue MF, Choesmel V, Faubladier M, Fichant G, Gleizes PE (2010) Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits. J. Cell Biol. 190: 853-866.
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Doherty L, Sheen MR, Vlachos A, Choesmel V, O’Donohue MF, Clinton C, Schneider HE, Sieff CA, Newburger PE, Ball SE, Niewiadomska E, Matysiak M, Glader B, Arceci RJ, Farrar JE, Atsidaftos E, Lipton JM, Gleizes PE, Gazda HT (2010) Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. Am. J. Hum. Genet. 86: 222-228
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Bellemer C, Chabosseau P, Gallardo F, Gleizes PE, Stahl G (2010) Genetic Interactions Show the Importance of rRNA Modification Machinery for the Role of Rps15p during Ribosome Biogenesis in S. cerevisiae. PLoS ONE 5: e10472
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Zemp I, Wild T, O'Donohue MF, Wandrey F, Widman B, Gleizes PE, and Kutay U (2009). Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2. J. Cell Biol. 185: 1167-80.
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Aguissa-Touré AH, Da Costa L, Leblanc T, Tchernia G, Fribourg S, Gleizes PE (2009) Anémie de Diamond-Blackfan : le côté obscur de la biogenèse des ribosomes. Med Sci, 25: 69-76.

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Gazda HT, Sheen MR, Vlachos A, Choesmel V, O'Donohue MF, H. S, Darras N, Hasman C, Sieff CA, Newburger PE, Ball SE, Niewiadomska E, Matysiak M, Zaucha JM, Glader B, Niemeyer C, Meerpohl JJ, Atsidaftos E, Lipton JM, Gleizes PE, Beggs AH (2008) Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. Am. J. Hum. Genet.83, 769-780.

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Crétien A, Hurtaud C, Moniz H, Proust A, Marie I, Wagner-Ballon O, Choesmel V, Gleizes PE, Leblanc T, Delaunay J, Tchernia G, Mohandas N, Da Costa L (2008). Study of the effects of proteasome inhibitors on ribosomal protein S19 (RPS19) mutants, identified in Diamond-Blackfan anemia patients. Hematologica 93:1627-1634.

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Campagnoli MF, Ramenghi U, Armiraglio M, Quarello P, Garelli E, Carando A, Avondo F, Pavesi E, Fribourg S, Gleizes PE, Loreni F, and Dianzani I (2008). RPS19 mutations in patients with Diamond-Blackfan anemia. Hum. Mutat. 29:911-920.

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Choesmel V, Fribourg S, Aguissa-Touré AH, Pinaud N, Legrand P, Gazda HT, Gleizes PE (2008) Mutation of ribosomal protein RPS24 in Diamond-Blackfan anemia results in a ribosome biogenesis disorder. Hum Mol Genet.17:1253-1263.
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Gregory LA, Aguissa-Touré AM, Pinaud N, Legrand P, Gleizes PE, Fribourg S (2007) Molecular basis of Diamond-Blackfan anemia: structure and function analysis of RPS19. Nucleic Acids Research, 35: 5913-21
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Choesmel V, Bacqueville D, Rouquette J, Noaillac-Depeyre J, Fribourg S, Cretien A, Leblanc T, Tchernia G, Da Costa L, Gleizes PE (2007) Impaired ribosome biogenesis in Diamond-Blackfan anemia. Blood  109: 1275-1283
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Ferreira-Cerca, S., Poll, G., Gleizes, P. E., Tschochner, H., and Milkereit, P. (2005). Roles of eukaryotic ribosomal proteins in maturation and transport of pre-18S rRNA and ribosome function. Mol. Cell 20, 263-275.
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Leger-Silvestre, I., Caffrey, J. M., Dawaliby, R., Alvarez-Arias, D. A., Gas, N., Bertolone, S. J., Gleizes, P. E., and Ellis, S. R. (2005). Specific Role for Yeast Homologs of the Diamond Blackfan Anemia-associated Rps19 Protein in Ribosome Synthesis. J. Biol. Chem. 280, 38177-38185.
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Rouquette, J., Choesmel, V., and Gleizes, P.E . (2005). Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammamlian cells. Embo J, 24, 2862-2872
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Léger-Silvestre, I., Milkereit, P., Ferreira-Cerca, S. , Saveanu, C., Rousselle, J. C., Choesmel, V., Guinefoleau, C., Gas, N., and Gleizes, P. E. (2004). The ribosomal protein Rps15p is required for nuclear exit of the 40S subunit precursors in yeast. Embo J,23, 2336-2347

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Bai, S.W., Rouquette, J., Umeda, M., Faigle, W., Loew, D., Sazer, S. and Doye, V. (2004) The Fission Yeast Nup107-120 Complex Functionally Interacts with the Small GTPase Ran/Spi1 and Is Required for mRNA Export, Nuclear Pore Distribution, and Proper Cell Division. Mol Cell Biol, 24, 6379-6392.

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Dez, C., Froment, C., Noaillac-Depeyre, J., Monsarrat, B., Caizergues-Ferrer, M. and Henry, Y. (2004) Npa1p, a Component of very early Pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification. Mol. Cell Biol., 24, 6324-6337.

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Jakovljevic, J., de Mayolo, P. A., Miles, T. D., Nguyen, T. M., Léger-Silvestre, I. , Gas, N., and Woolford, J. L., Jr. (2004). The carboxy-terminal extension of yeast ribosomal protein S14 is necessary for maturation of 43S preribosomes. Mol. Cell,14, 331-342.

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Milkereit, P. , Kuhn, H., Gas, N., and Tschochner, H. (2003). The pre-ribosomal network. Nucleic Acids Res,31, 799-804.

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Milkereit, P. , Strauss, D., Bassler, J., Gadal, O., Kuhn, H., Schutz, S., Gas, N., Lechner, J., Hurt, E., and Tschochner, H. (2003). A noc complex specifically involved in the formation and nuclear export of ribosomal 40 s subunits. J. Biol. Chem.,278, 4072-4081.

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Saveanu, C., Namane, A., Gleizes, P. E., Lebreton, A., Rousselle, J. C., Noaillac-Depeyre, J., Gas, N., Jacquier, A., and Fromont-Racine, M. (2003). Sequential protein association with nascent 60S ribosomal particles. Mol. Cell. Biol.,23, 4449-4460.

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Vanrobays, E., Gélugne, J.-P., Gleizes, P.-E., Caizergues-Ferrer, M. (2003). Late cytoplasmic maturation of the small ribosomal sub-unit requires RIO proteins in yeast. Mol. Cell. Biol. , 23, 2083-2095 .

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Olichon, A., Baricault, L., Gas, N., Guillou, E., Valette, A., Belenguer, P., and Lenaers, G. (2003). Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J Biol Chem,278, 7743-7746 .

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Gadal, O., Strauss, D., Petfalski, E., Gleizes, P.E., Gas, N., Tollervey, D. and Hurt, E. (2002) Rlp7p is associated with 60S preribosomes, restricted to the granular component of the nucleolus, and required for pre-rRNA processing. J. Cell Biol., 157, 941-951.

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Dez, C., Noaillac-Depeyre, J., Caizergues-Ferrer, M. and Henry, Y. (2002) Naf1p, an essential nucleoplasmic factor specifically required for accumulation of box H/ACA small nucleolar RNPs. Mol. Cell. Biol., 22, 7053-7065.
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Olichon, A., Emorine, L.J., Descoins, E., Pelloquin, L., Brichese, L., Gas, N., Guillou, E., Delettre, C., Valette, A., Hamel, C.P., Ducommun, B., Lenaers, G. and Belenguer, P. (2002) The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett., 523, 171-176.

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Gleizes, P. E., Noaillac-Depeyre, J., Leger-Silvestre, I., Teulieres, F., Dauxois, J. Y., Pommeret, D., Azum-Gelade, M. C., and Gas, N. (2001). Ultrastructural localization of rRNA shows defective nuclear export of preribosomes in mutants of the Nup82p complex. J Cell Biol,155, 923-936.

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Vanrobays, E., Gleizes, P.-E., Bousquet-Antonelli, C., Noaillac-Depeyre, J., Caizergues-Ferrer, M., Gélugne, J.-P. (2001) Processing of 20S pre-rRNA to 18S ribosomal RNA in yeast requires Rrp10p, an essential non-ribosomal cytoplasmic protein. Embo J.,20, 4204-4213.

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Milkereit, P., Gadal, O., Podtelejnikov, A., Trumtel, S., Gas, N., Petfalski, E., Tollervey, D., Mann, M., Hurt, E., and Tschochner, H. (2001). Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Cell ,105, 499-509 .

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Saveanu, C., Bienvenu, D., Namane, A., Gleizes, P. E., Gas, N., Jacquier, A., and Fromont-Racine, M. (2001). Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps. Embo J ,20, 6475-6484




Laboratoire de Biologie
Moléculaire Eucaryote
UMR 5099

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