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Laboratoire de Biologie Moléculaire Eucaryote

UMR 5099
Director: Pierre-Emmanuel Gleizes


The LBME (Laboratory/Department of Eukaryotic Molecular Biology) (UMR 5099) is comprised of eight research groups, located in the CNRS building (IBCG) on the Rangueil Paul Sabatier University campus in Toulouse, France.


Research themes :
Our research interests are the genetic and epigenetic control of eukaryotic gene expression in normal and pathological contexts. Two major themes are addressed:

  • the structural and functional characterization of RiboNucleoParticles, nuclear or nucleolar (telomerase, snoRNPs, scaRNPs, pre-ribosomes, 7SK …)
  • the dynamic structure of chromatin in relation to the transcriptional activity of genes and homologous recombination





Senior Post-doc positions


News :


  • Chromatin structure and gene looping regulate expression of the Cyclin D1 gene in breast cancer cells.

  • We demonstrate that release of intragenic chromatin looping is required for rapid transcription activation in response to stimuli, in particular estrogen.


    H2A.Z-dependent crosstalk between enhancer and promoter regulates Cyclin D1 expression.
    Dalvai M, Bellucci L, Fleury L, Lavigne AC, Moutahir F, Bystricky K. Oncogene. 2012 Oct 29. doi: 10.1038/onc.2012.442 (Pubmed).


    TIP48/Reptin and H2A.Z Requirement for Initiating Chromatin Remodeling in Estrogen-Activated Transcription
    Mathieu Dalvai, Laurence Fleury, Luca Bellucci, Silvia Kocanova, Kerstin Bystricky Research Article | published 18 Apr 2013 | PLOS Genetics 10.1371/journal.pgen.1003387 (Pubmed).


    Learn more ...


    Mathieu Dalvai



  • RNA elements directing the assembly of the 7SK 'core' RNP

  • Researchers from the LBME (Toulouse, France) have determined the sequence and structural elements of human 7SK snRNA directing assembly of the 7SK 'core' snRNP, that coordinates specific recruitment and inhibition of the general Pol II transcription elongation factor, P-TEFb. This work has been reported in Nucleic Acids Research in March 2013.


    Muniz L, Egloff S, Kiss T. (2013) RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP. Nucleic Acids Res. [Pubmed]


    Lisa Muniz


  • Microprocessor dynamics and interactions at endogenous imprinted C19MC microRNA genes

  • Researchers from the LBME (Toulouse, France), the IGMM (Montpellier, France) and the Aarhus University (Denmark) have recently developed a cell imaging approach that enables the visualization of microRNA biogenesis in living human cells and at the level of a single microRNA cluster. Their work is described in details in an article of the Journal of Cell Science.

    Read more ...



FRBT seminars

Cell nuclei-nucleoid club


SnoRNA-db: a comprehensive database of human H/ACA and C/D box snoRNAs.

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Laboratoire de Biologie
Moléculaire Eucaryote
UMR 5099